How Much Benadryl Can I Give My Dog? A Pet Parent’s Guide

Amelia Taylor (Vet) – Cornell University College of Veterinary Medicine


As loving pet owners, we always want to comfort our dogs when they’re in pain, particularly during allergy season, after an insect bite, or when they experience an unexpected skin reaction. Veterinarians frequently get the following query:

Can Dogs Take Benadryl Without Risk?

Yes, when taken as directed by a veterinarian, Benadryl is usually safe for dogs. It is frequently used to treat:

  • Allergies (environmental or seasonal)
  • Hives and itching
  • Insect bites and stings
  • Travel anxiety (mild sedation effect)
  • Vaccine reactions

Important: Before giving your pet any medication, always get advice from your veterinarian.

Dog WeightBenadryl Dose (mg)
10 lbs10mg
25 Ibs25mg
50 Ibs50mg
75 Ibs75mg


Use plain Benadryl tablets or capsules without any added ingredients like acetaminophen, decongestants, or alcohol.

How Much Benadryl Can I Give My Dog

When Not to Give Benadryl?

Avoid giving Benadryl if your dog has:

  • Glaucoma
  • High blood pressure
  • Seizure disorders
  • Heart disease
  • Pregnancy (consult vet)

Track Symptoms with the FLUTO Pet Super App

fluto pre launch

Rather than guessing, keep your dog’s allergy symptoms, medications, and reactions organized and monitored in one place. The Fluto App helps pet parents:
• 📅 Track allergy flare-ups and medications
• 🧠 Monitor changes in behavior or mood
• 🔔 Get reminders for next dosage
• 📷 Upload pictures of rashes or reactions for vet visits and get AI insights
• 💬 Ask AI-powered questions about pet health 24/7

Final Tips Before Giving Benadryl

  • Use children’s liquid Benadryl only if it’s free from xylitol (a toxic sweetener for dogs).
  • Watch for side effects like drowsiness, dry mouth, or upset stomach.
  • Don’t mix with other sedatives or antihistamines.